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Visudyne ®  (verteporfin for injection)


Visudyne (pronounced vis-U-dine)


Generic name:  verteporfin (pronounced ver-te-POOR-phin)


You should read this information before you talk with your doctor about Visudyne.  This article provides a
summary of certain information about Visudyne.  Your doctor can talk with you about Visudyne in more
detail, including information about what to expect and potential side effects.  Visudyne is given to patients
in a doctors office by a qualified health professional.


What is Visudyne?


Visudyne is the first available drug therapy for people with a certain form of age-related macular
degeneration (AMD) known as predominantly classic wet AMD.  Visudyne slows the progression of vision
loss that is caused by predominantly classic wet AMD.  Your doctor will determine if Visudyne therapy is the
right choice for you.


Visudyne is given by injection and is activated by a non-heat producing laser light.  Three  to six weeks after
Visudyne therapy, a doctor examines the patient to determine if retreatment is necessary.  More
information is available about Visudyne at the website  www.Visudyne.com.


What is age-related macular degeneration (also know as AMD)?


AMD is a disease that affects a persons vision.  It usually happens in people who are 50 years or older.  
There are two types of AMD.  About 90% of the people who develop AMD have the dry form, in which
vision deteriorates slowly or not at all.  The other 10% of people have the wet form of AMD.  In wet AMD,
normal blood vessels form in the back of the eye and damage vision.  Wet AMD is characterized by two
patterns, classic and occult.  Most patients have a combination of both patterns, and Visudyne therapy is
beneficial when the AMD is predominantly or mostly classic.  Many people who develop wet AMD suffer
from severe vision loss in 2 to 3 years.


How does Visudyne work?


Wet AMD occurs when abnormal blood vessels grow under the macula, the part of the eye that gives
people their central vision.


Visudyne is injected into the bloodstream, usually through a person's arm.  Visudyne travels to the abnormal
new blood vessels including those associated with AMD.  A short while after the Visudyne is injected, the
doctor shines a non-heat producing laser light into the patient's eye.  The light activates the Visudyne.  After
it is activated, the Visudyne starts a chemical process (oxidation) that destroys the abnormal blood vessels.


Visudyne can slow the progression of vision loss that is caused by predominantly classic wet AMD.  After
one year of treatment, people who were given Visudyne had significantly less vision loss than those who
received placebo therapy.




How is Visudyne therapy given?

Visudyne is injected into the bloodstream, usually through the patient's arm.  A short while after Visudyne is
injected, the doctor shines a non-heat producing laser light into the patient's eye.  The light activates the
Visudyne.

Patients are examined every 6 weeks to 3 months by a doctor to determine if another treatment is
necessary.

Visudyne causes temporary sensitivity to light (photosensitivity) for 2-5 days.

The safety and effectiveness of Visudyne therapy beyond 2 years have not been shown.


Who should not be given Visudyne?


People with porphyria or allergies to any of the ingredients of Visudyne should not be given Visudyne.  Your
doctor has a list of the ingredients of Visudyne.


What should I know about Visudyne ?


Patients who receive Visudyne will become temporarily sensitive to light (photosensitivity).  Patients should
wear a temporary wristband to remind them to avoid direct sunlight for 5 days.  


During that time, patients should avoid exposure of unprotected skin, eyes or other body organs to direct
sunlight or bright indoor light.  This includes, but is not limited to, tanning salons, bright halogen lighting and
high power lighting used in surgical operating rooms or dental offices.


Treated patients who have to go outdoors in daylight during the first 5 days after treatment must protect all
parts of their skin and their eyes by wearing protective clothing and dark sunglasses. UV sunscreens are
not effective in protecting against photosensitivity reactions because photoactivation of the residual drug in
the skin can be caused by visible light.


Indoors, patients should not stay in the dark and should be encouraged to expose their skin to normal
indoor light, because it will help inactivate the drug in the skin through a process called photobleaching.


What are the possible side effects of Visudyne?


In studies, side effects did not usually cause patients to stop Visudyne therapy.

Below is a list of some side effects reported with Visudyne therapy.  Your doctor can inform you of the
complete list of side effects.  Some of the most commonly reported side effects include:

  • Injection site reactions
  • Visual disturbances (including blurred vision, decreased visual acuity, and visual field defects)


In addition, the side effects listed below were reported in fewer patients.

Eye:  Cataracts, conjunctivitis/conjunctival injection, dry eyes, ocular itching, severe vision loss,
subconjunctival, subretinal or vitreous hemorrhage.
Body as a whole:  Weakness, back pain, fever, flu syndrome, sensitivity reaction to light.
Heart:  Atrial fibrillation, peripheral vascular disorder, hypertension, varicose veins
Skin:  Eczema.
Digestive:  Constipation, gastrointestinal cancers, nausea.
Hemic and lymphatic:  Anemia, increased white blood cell count, decreased white blood cell count.
Hepatic:  Elevated liver function tests.
Metabolic/nutritional:  Albuminuria, creatinine increased.
Musculoskeletal:  Arthralgia, arthrosis, myasthenia.
Nervous system:  Hypesthesia, sleep disorder, vertigo.
Respiratory:  Pharyngitis, pneumonia.
Special senses:  Decreased hearing, diplopia, lacrimation disorder.
Urogenital:  Prostatic disorder.



This article provides a summary of information about Visudyne.  If you have any questions about
Visudyne or AMD, talk to your doctor.  Your doctor can give you additional information about Visudyne
that is written for health professionals .


©  Copyright 1999 Dialog Medical, Inc.  All rights reserved.


Midwest Retina Associates, Inc.